TwoStateHillSwitch.h

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/*
 * University of Illinois Open Source License
 * Copyright 2010-2018 Luthey-Schulten Group,
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 * Developed by: Luthey-Schulten Group
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 * Author(s): Elijah Roberts
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#ifndef LM_CME_TWOSTATEHILLSWITCH_H_
#define LM_CME_TWOSTATEHILLSWITCH_H_
 
#include <cmath>
#include <map>
#include <string>
 
using std::string;
using std::map;
 
namespace lm {
namespace cme {
 
class TwoStateHillSwitch: public GillespieDSolver
{
protected:
    struct KHillPropensityArgs
    {
        KHillPropensityArgs(uint si, uint xi, double kmin, double kmax, double x50, double h) :si(si),xi(xi),kmin(kmin),kmax(kmax),dk(kmax-kmin),x50ph(pow(x50,h)),h(h) {}
        ~KHillPropensityArgs() {}
        uint si;
        uint xi;
        double kmin;
        double kmax;
        double dk;
        double x50ph;
        double h;
    };
 
public:
    TwoStateHillSwitch();
    virtual ~TwoStateHillSwitch();
    virtual bool needsReactionModel() {return false;}
    virtual bool needsDiffusionModel()  {return false;}
    virtual void generateTrajectory();
    virtual void runConstantProtein();
    virtual void runGeometricProtein();
    
protected:
    static double kHillPropensity(double time, uint * speciesCounts, void * pargs);
    static double negativeKHillPropensity(double time, uint * speciesCounts, void * pargs);
};
 
}
}
 
#endif